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Time-dependent cell-state picking

Y. Tanaka, M. Yamagishi, .., K. Moro, S. Uemura, and Y. Shirasaki, "Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation", Communications Biology (2023)

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Intelligent sorting of yeast

M. Hayashi, S. Ohnuki, Y. Tsai, .., A. Isozaki, Y. Ohya, and K. Goda, "Is AI essential? Examining the need for deep learning in image-activated sorting of Saccharomyces cerevisiae", Lab on a Chip (2023)

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Inertial sorting of particles

T. Zhang, D. W. Inglis, .., Y. Hosokawa, Y. Yalikun, and M. Li, "Inertial separation of particles assisted by symmetrical sheath flows in a straight microchannel", Analytical Chemistry (2023)

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Laser-guided neuron growth

D. Anggraini, T. Zhang, X. Liu, M. Li, Y. Hosokawa, S. Yamada, and Y. Yalikun, "Guided axon outgrowth of neurons by molecular gradients generated from femtosecond laser-fabricated micro-holes", Talanta (2023)

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Improved Raman tags

R. Nishiyama, K. Furuya, .., B. W. Laursen, A. H. Flood, K. Hiramatsu, and K. Goda, "Boosting the brightness of Raman tags using cyanostar macrocycles", Analytical Chemistry (2023)

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Microfluidic bacteria screening

T. Zhang, A. K. Cain, L. Semenec, J. V. Pereira, Y. Hosokawa, Y. Yalikun, and M. Li, "Bacteria separation and enrichment using viscoelastic flows in a straight microchannel", Sensors and Actuators B: Chemical (2023)

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Intelligent impedance cytometry

T. Tang, T. Julian, D. Ma, Y. Yang, M. Li, Y. Hosokawa, and Y. Yalikun, "A review on intelligent impedance cytometry systems: Development, applications and advances", Analytica Chimica Acta (2023)

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Ultrafast flow cytometry

X. Liu, J. Zhou, R. Yan, T. Tang, S. Wei, .., M. Li, Y. Hosokawa, Y. Yalikun, and C. Lei, "An optimized PDMS microfluidic device for ultra-fast and high-throughput imaging flow cytometry", Lab on a Chip (2023)

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CRISPR-powered sensing

H. Duan, .., and M. Li, "A CRISPR-Cas12a powered electrochemical sensor based on gold nanoparticles and MXene composite for enhanced nucleic acid detection", Sensors and Actuators B: Chemical (2023)

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Microalgal starch screening

J. Gala de Pablo, M. Lindley, K. Hiramatsu, A. Isozaki, and K. Goda, "Label-free live microalgal starch screening via Raman flow cytometry", Algal Research (2023)


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Fast hyperspectral imaging

S. Takizawa, K. Hiramatsu, M. Lindley, J. Gala de Pablo, S. Ono, and K. Goda, "High-speed hyperspectral imaging enabled by compressed sensing in time domain", Advanced Photonics Nexus (2023)

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Multiphoton flow cytometry

R. Kinegawa, J. Gala de Pablo, Y. Wang, K. Hiramatsu, and K. Goda, "Label-free multiphoton imaging flow cytometry", Cytometry Part A (2023)



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Time-stretch imaging

R. Li,Y. Weng, S. Lin, C. Wei, L. Mei, S. Wei, .., K. Goda, and C. Lei, "All-optical Fourier-domain-compassed time-stretch imaging with low-pass filtering", ACS Photonics (2023)

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Super-multiplex flow cytometry

R. Nishiyama, K. Hiramatsu, S. Kawamura, K. Dodo, K. Furuya, J. Gala de Pablo, S. Takizawa, W. Min, M. Sodeoka, and K. Goda, "Color-scalable flow cytometry with Raman tags", PNAS Nexus (2023)

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COVID-19 and thrombosis

C. Zhang, M. Herbig, Y. Zhou, M. Nishikawa, .., Y. Yatomi, and K. Goda, "Real-time intelligent classification of COVID-19 and thrombosis via massive image-based analysis of platelet aggregates", Cytometry Part A (2023)

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Typing of accute leukemia

Y. Weng, H. Shen, L. Mei, L. Liu, Y. Yao, R. Li, S. Wei, .., K. Goda, S. Liu, F. Zhou, and C. Lei, "Typing of acute leukemia by intelligent optical time-stretch imaging flow cytometry", Lab on a Chip (2023)

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Convenient SERS

Y. Kitahama, P. M. Pancorbo, H. Segawa, .., W. Yang, and K. Goda, "Place & Play SERS: sample collection and preparation-free surface-enhanced Raman spectroscopy", Analytical Methods (2023)

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Microfluidic cell screening

T. Zhang, A. K. Cain, L. Semenec, L. Liu, .., Y. Yalikun, and M. Li, "Microfluidic separation and enrichment of Escherichia coli by size using viscoelastic flows", Analytical Chemistry (2023)

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CTC detection

H. Matsumura, .., K. Goda, and S. Matsusaka, "Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling", Lab on a Chip (2023)

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Cell sorting by femtosecond laser

R. Kiya, T. Tang, Y. Tanaka, Y. Hosokawa, and Y. Yalikun, "Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser", Scientific Reports (2022)

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Flow velocity sensing

Y. Hao, C. Fang, Y. Yuan, K. Okano, .., M. Li, and Y. Yalikun, "Multi-position measurable flow velocity sensor for microfluidic applications", IEEE Sensors Journal (2022)


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Efficacy of antiplatelet drugs

Y. Deng, H. M. Tay, Y. Zhou, X. Fei, .., H. W. Hou, T. Xiao, and K. Goda, "Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip", Lab on a Chip (2022)

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GFP selection

R. Iizuka, .., S. Shoji, and T. Funatsu, "Selection of green fluorescent proteins by in vitro compartmentalization using microbead-display libraries", Biochemical Engineering Journal (2022)

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Myeloma detection

L. Mei, H. Shen, Y. Yu, Y. Weng, .., F. Zhou, and C. Lei, "High-throughput and high-accuracy diagnosis of multiple myeloma with multi-object detection", Biomedical Optics Express (2022)


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Adversarial feature learning

L. Mei, Y. Yu, H. Shen, Y. Weng, Y. Liu, .., and C. Lei, "Adversarial multiscale feature learning framework for overlapping chromosome segmentation", Entropy (2022)


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Impedance cytometry

T. Tang, X. Liu, Y. Yuan, .., M. Li, Y. Hosokawa, and Y. Yalikun, "Dual-frequency impedance assays for intracellular components in microalgal cells", Lab on a Chip (2022)


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Ultrafast Raman spectroscopy

K. Hiramatsu, T. Tajima, and K. Goda, "Ultrafast, dual-band coherent Raman spectroscopy without ultrashort pulses", ACS Photonics (2022)



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Wearable/Flexible SERS

L. Liu, S. Noguchi, T. Xiao, S. Karhadkar, K. Hiramatsu, H. Segawa, T. Itoh, J. Qu, K. Takei, and K. Goda, "Highly scalable, wearable surface-enhanced Raman spectroscopy", Advanced Optical Materials (2022)

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3D particle manipulation

Y. Shen, Y. Yuan, T. Tang, N. Ota, N. Tanaka, Y. Hosokawa, Y. Yalikun, and Y. Tanaka, "Continuous 3D particles manipulation based on cooling thermal convection", Sensors and Actuators B: Chemical (2022)

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Cell component tracking

T. Tang, X. Liu, Y. Yuan, .., M. Li, Y. Hosokawa, and Y. Yalikun, "Impedance-based tracking of the loss of intracellular components in microalgae cells", Sensors and Actuators B: Chemical (2022)

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Broadband impulsive Raman

W. Peterson, J. Gala de Pablo, M. Lindley, K. Hiramatsu, and K. Goda, "Ultrafast impulsive Raman spectroscopy across the THz-fingerprint region", Advanced Photonics (2022)

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Gas velocity sensor

Y. Hao, Y. Tanaka, Y. Hosokawa, M. Li, and Y. Yalikun, "A gas flow velocity sensor fabricated with femtosecond laser using 4 μm ultra-thin glass sheet", Applied Physics Express (2022)

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Microfluidic cell cultivation

D. Anggraini, N. Ota, Y. Shen, T. Tang, Y. Tanaka, Y. Hosokawa, M. Li, and Y. Yalikun, "Recent advances in microfluidic devices for single-cell cultivation: methods and applications", Lab on a Chip (2022)

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Mitochondrial relocation sorting

J. Harmon, J. Findinier, N. T. Ishii, M. Herbig, A. Isozaki, A. Grossman, and K. Goda, "Intelligent image-activated cell sorting by mitochondrial relocation", Cytometry Part A (2022)


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Fingerprint cell sorting

M. Lindley, J. Gala de Pablo, W. Peterson, A. Isozaki, K. Hiramatsu, K. Goda, "High-throughput Raman-activated cell sorting in the fingerprint region", Advanced Materials Technologies (2022)

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Stenosis imaging

Y. Deng, J. A. Duque, .., M. Nishikawa, T. Xiao, Y. Yatomi, H. W. Hou, and K. Goda, "Understanding stenosis-induced platelet aggregation on a chip by high-speed optical imaging", Sensors and Actuators B: Chemical (2022)

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Cell membrane analysis

T. Tang, X. Liu, Y. Yuan, .., M. Li, Y. Hosokawa, and Y. Yalikun, "Assessment of the electrical penetration of cell membranes using four-frequency impedance cytometry", Microsystems & Nanoengineering (2022)

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Impedance cytometry of yeast

X. Liu, T. Tang, P. Yi, Y. Yuan, C. Lei, M. Li, Y. Tanaka, Y. Hosokawa, and Y. Yalikun,"Identification of single yeast budding using impedance cytometry with a narrow electrode span", Sensors (2022)

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Throughput practices

M. Herbig, A. Isozaki, D. Di Carlo, J. Guck, N. Nitta, H. Shintaku, A. Wu, I. Nikaido, .., R. Damoiseaux, and K. Goda, "Best practices for reporting throughput in biomedical research", Nature Methods (2022)

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Parallel impedance cytometry

T. Tang, X. Liu, Y. Yuan, .., Y. Tanaka, M. Li, Y. Hosokawa, and Y. Yalikun, "Parallel impedance cytometry for real-time screening of bacterial single cells from nano- to microscale", ACS Sensors (2022)

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Sort-timing prediction

Y. Zhao, A. Isozaki, M. Herbig, M. Hayashi, K. Hiramatsu, .., S. Ohnuki, Y. Ohya, N. Nitta, and K. Goda, "Intelligent sort-timing prediction for image-activated cell sorting", Cytometry Part A (2022)

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Sorting of imMKCLs

A. Dian, W. Mubarok, .., S. Suetsugu, and Y. Yalikun, "Reverse sorting of immortalized megakaryocyte progenitor cell lines (imMKCLs) by femtosecond laser scanning", Applied Physics Express (2022)

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COVID-19 vaccination effect

Y. Zhou, M. Nishikawa, H. Kanno, R. Yang, .., Y. Kanthi, G. K. Rohde, K. Moriya, Y. Yatomi, and K. Goda, "Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets", Cytometry Part A (2022)

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Shape-based separation

T. Zhang, H. Liu, .., Y. Tanaka, D. W Inglis, Y. Hosokawa, Y. Yalikun, and M. Li, "Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics", Lab on a Chip (2022)

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Review of metal-free SERS

P. M. Pancorbo, H. Zhang, X. Yu, T. Xiao, and K. Goda, "Metal-free SERS: where we are now, where we are heading", Europhysics Letters (2022)



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AI-based impedance screening

T. Tang, X. Liu, .., and Y. Yalikun, "Machine learning-based impedance system for real-time recognition of antibiotic-susceptible bacteria with parallel cytometry", Sensors and Actuators B: Chemical (2022)

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Deep imaging flow cytometry

K. Huang, H. Matsumura, .., J. Harmon, J. Findinier, M. Yamagishi, S. Ohnuki, N. Nitta, A. Grossman, Y. Ohya, H. Mikami, A. Isozaki, and K. Goda, "Deep imaging flow cytometry", Lab on a Chip (2022)

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Review of ultrafast imaging

D. Wang, S. Wei, X. Yuan, Z. Liu, Y. Weng, Y. Zhou, T. Xiao, K. Goda, S. Liu, and C. Lei, "Ultrafast imaging for uncovering laser-material interaction dynamics", International Journal of Mechanical System Dynamics (2022)

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COVID-19-associated thrombosis

M. Nishikawa, H. Kanno, Y. Zhou, .., Y. Yatomi, and K. Goda, "Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19", Nature Communications (2021)

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Lactate indicator

R. Bekdash, J. R. Quejada, S. Ueno, F. Kawano, K. Morikawa, .., S. O. Marx, K. Goda, and M. Yazawa, "GEM-IL: a highly responsive fluorescent lactate indicator", Cell Reports Methods (2021)

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Sepsis therapy

H. Koide,.., T. Xiao, K. Goda, N. Oku, T. Asai, and K. J. Shea, "Synthetic hydrogel nanoparticles for sepsis therapy", Nature Communications (2021)


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Dielectrophoretic array sorting

M. H. Loo, Y. Nakagawa, A. Isozaki, and K. Goda, "High-throughput sorting of nanoliter droplets enabled by a sequentially addressable dielectrophoretic array", Electrophoresis (2021)

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Sensitive FT-CARS

M. Lindley, .., K. Hiramatsu, and K. Goda, "Highly sensitive Fourier-transform coherent anti-Stokes Raman scattering spectroscopy via genetic algorithm pulse shaping", Optics Letters (2021)

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Reassessing microdroplets

Y. Nakagawa, S. Ohnuki, N. Kondo, .., A. Isozaki, Y. Ohya, and K. Goda, "Are droplets really suitable for single-cell analysis? A case study on yeast in droplets", Lab on a Chip (2021)


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Low-frequency Raman

P. C. McCann, K. Hiramatsu, and K. Goda, "Highly sensitive low-frequency time-domain Raman spectroscopy via fluorescence-encoding", Journal of Physical Chemistry Letters (2021)


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Multiplexed droplet sorting

A. Isozaki, D. Huang, Y. Nakagawa, and K. Goda, "Dual sequentially addressable dielectrophoretic array for high-throughput, scalable, multiplexed droplet sorting", Microfluidics and Nanofluidics (2021)

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Ca2+ channel control

P. Cheng, X. Tian, W. Tang, J. Cheng, J. Bao, .., K. Goda, and H. He, "Direct control of store-operated calcium channels by ultrafast laser", Cell Research (2021)


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Review of droplet flow cytometry

M. Li, H. Liu, S. Zhuang, and K. Goda, "Droplet flow cytometry for single-cell analysis", RSC Advances (2021)




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Review of glass microfluidics

T. Tang, Y. Yuan, .., M. Li, and Y. Tanaka, "Glass-based micro total analysis systems: materials, fabrication methods, and applications", Sensors and Actuators B: Chemical (2021)


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Sensitive Raman optical activity

T. Xiao, Z. Cheng, Z. Luo, A. Isozaki, K. Hiramatsu, T. Itoh, M. Nomura, S. Iwamoto, and K. Goda, "All-dielectric chiral-field-enhanced Raman optical activity", Nature Communications (2021)

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Intelligent cell indicator

M. Xu, D. Yuan, S. Yan, C. Lei, .., K. Goda, "Morphological indicator of Euglena gracilis with a high heavy metal removal efficiency", Environmental Science and Technology (2021)

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Deep biophysical cytometry

K. C. M. Lee, J. Guck, K. Goda, and K. K. Tsia, "Deep biophysical cytometry: prospects and challenges", Trends in Biotechnology (2021)



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Review of Raman flow cytometry

J. Gala de Pablo, M. Lindley, K. Hiramatsu, and K. Goda, "High-throughput Raman flow cytometry and beyond", Accounts of Chemical Research (2021)


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Intelligent platelet morphometry

Y. Zhou, A. Isozaki, A. Yasumoto, T. Xiao, Y. Yatomi, C. Lei, and K. Goda, "Intelligent platelet morphometry", Trends in Biotechnology (2021)



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Ultrathin glass microfluidics

Y. Yuan, Y. Yalikun, .., Y. Shen, and Y. Tanaka, "Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching", Sensors and Actuators A: Physical (2021)

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Cell control by light

P. Cheng, X. Tian, W. Tang, J. Cheng, J. Bao, H. Wang, .., T. Chen, H. Feng, T. Xue, K. Goda, and H. He, "Direct control of store-operated calcium channels by ultrafast laser", Cell Research (2021)

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Hydrodynamic particle focusing

T. Zhang, M. Namoto, .., Y. Yalikun, M. Li, Y. Hosokawa, "Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers", Scientific Reports (2021)

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Cell rotation

T. Tang, Y. Hosokawa, T. Hayakawa, Y. Tanaka, W. Li, M. Li, and Y. Yalikun, "Rotation of biological cells: fundamentals and applications", Engineering (2021)


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Efficient coherent Raman

R. Kameyama, S. Takizawa, K. Hiramatsu, and K. Goda, "Dual-comb coherent Raman spectroscopy with near 100% duty clcle", ACS Photonics (2020)


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Metal-free SERS

N. Chen, T. Xiao, Z. Luo, Y. Kitahama, N. Kishimoto, T. Ito, Z. Cheng, and K. Goda, "Porous carbon nanowire array for surface-enhanced Raman spectroscopy", Nature Communications (2020)

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Yeast screening by shape

P. Liu, H. Liu, D. Yuan, D. Jang, S. Yan, and M. Li, "Separation and enrichment of yeast Saccharomyces cerevisiae by shape using viscoelastic microfluidics", Analytical Chemistry (2020)


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Raman image-based cell sorting

N. Nitta, T. Iino, A. Isozaki, M. Yamagishi, Y. Kitahama, S. Sakuma, .., and K. Goda, "Raman image-activated cell sorting", Nature Communications (2020)


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AI on a chip

A. Isozaki, J. Harmon, Y. Zhou, S. Li, Y. Nakagawa, M. Hayashi, H. Mikami, C. Lei, and K. Goda, "AI on a chip", Lab on a Chip (2020)



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Time-stretch imaging

Y. Weng, L. Mei, G. Wu, S. Chen, B. Zhan, K. Goda, S. Liu, and C. Lei, "Analysis of signal detection configurations in optical time-stretch imaging", Optics Express (2020)


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Mechanical properties of cells

Y. Hao, S. Cheng, Y. Tanaka, Y. Hosokawa, Y. Yalikun, and M. Li, "Mechanical properties of single cells: Measurement methods and applications", Biotechnology Advances (2020)

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Dielectrophoretic array sorting

A. Isozaki, Y. Nakagawa, .., D. Di Carlo, and K. Goda, "Sequentially addressable dielectrophoretic array for high-throughput sorting of large-volume biological compartments", Science Advances (2020)

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Image-activated cell sorting 2.0

A. Isozaki, H. Mikami, H. Tezuka, H. Matsumura, K. Huang, .., T. Sugimura, N. Nitta, and K. Goda, "Intelligent image-activated cell sorting 2.0", Lab on a Chip (2020)


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Virtual-freezing imaging

H. Mikami, M. Kawaguchi, C.-J. Huang, H. Matsumura, .., S. Matsusaka, C.-W. Sun, Y. Ozeki, and K. Goda, "Virtual-freezing fluorescence imaging flow cytometry", Nature Communications (2020)

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Platelet aggregate classification

Y. Zhou, A. Yasumoto, C. Lei, C.-J. Huang, H. Kobayashi, Y. Wu, S. Yan, C.-W. Sun, Y. Yatomi, and K. Goda, "Intelligent classification of platelet aggregates by agonist type", eLife (2020)

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Virtual time-stretch imaging

H. Yan, Y. Wu, Y. Zhou, M. Xu, P. Paie, C. Lei, S. Yan, and K. Goda, "Virtual optofluidic time-stretch quantitative phase imaging", APL Photonics (2020)



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Spatiotemporal cell monitoring

Y. Yonamine, K. Hiramatsu, .., and Y. Hoshino, "Spatiotemporal monitoring of intracellular metabolic dynamics by resonance Raman microscopy with stable isotope labeling", RSC Advances (2020)

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Large-scale single-cell analysis

K. Hiramatsu, .., and K. Goda, "Large-scale label-free single-cell analysis of paramylon in Euglena gracilis by high-throughput broadband Raman flow cytometry", Biomedical Optics Express (2020)

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Ultrafast single-pixel imaging

H. Kanno, H. Mikami, and K. Goda, "High-speed single-pixel imaging by frequency-time-division multiplexing", Optics Letters (2020)



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Temporally interleaved imaging

Y. Weng, G. Wu, L. Mei, Q. Wang, K. Goda, S. Liu, and C. Lei, "Temporally interleaved optical time-stretch imaging", Optics Letters (2020)



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Glass microfluidics

Y. Yalikun, O. Nobutoshi, D. Ma, and Y. Tanaka, "Horizontal connection method for glass microfluidic devices", Micro & Nano Letters (2020)



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Compressed coherent Raman

S. Takizawa, K. Hiramatsu, and K. Goda, "Compressed time-domain coherent Raman spectroscopy with real-time random sampling", Vibrational Spectroscopy (2020)


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Accurate cell classification

J. Harmon, H. Mikami, .., and K. Goda, "High-speed accurate classification of microalgae by intelligent frequency-division-multiplexed fluorescence imaging flow cytometry", OSA Continuum (2020)

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Quantitative phase imaging

Y. Wu, Y. Zhou, C.-J. Huang, H. Kobayashi, S. Yan, .., Y. Yatomi, C. Lei, and K. Goda, "Intelligent frequency-shifted optofluidic time-stretch quantitative phase imaging", Optics Express (2020)

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Microfluidic chip deformation

Y. Yalikun, N. Ota, B. Guo, T. Tang, C. Lei, .., D. Di Carlo, K. Goda, and Y. Tanaka, "Effects of flow-induced microfluidic chip wall deformation on imaging flow cytometry", Cytometry Part A (2019)

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Ultrafast fluoRaman spectroscopy

M. Lindley, K. Hiramatsu, H. Nomoto, F. Shibata, T. Takeshita, S. Kawano, and K. Goda, "Ultrafast simultaneous Raman-fluorescence spectroscopy", Analytical Chemistry (2019)


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Focusing of submicron particles

T. Zhang, Z.-Y. Hong, S.-Y. Tang, W. Li, D. W. Inglis, Y. Hosokawa, Y. Yalikun, and M. Li, "Focusing of sub-micrometer particles in microfluidic devices", Lab on a Chip (2019)


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Low-frequency Raman

W. Peterson, K. Hiramatsu, and K. Goda, "Sagnac-enhanced impulsive stimulated Raman scattering for highly sensitive low-frequency Raman spectroscopy", Optics Letters (2019)


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Ultrafast particle isolation

T. Iino, K. Okano, .., K. Goda, and Y. Hosokawa, "High-speed microparticle isolation unlimited by Poisson statistics", Lab on a Chip (2019)



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Sheathless separation of microbes

D. Yuan, Q. Zhao, S. Yan, .., M. Li, and W. Li, "Sheathless separation of microalgae from bacteria using a simple straight channel based on viscoelastic microfluidics", Lab on a Chip (2019)

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Intelligent chemosensitivity testing

H. Kobayashi, C. Lei, .., Y. Yatomi, and K. Goda, "Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia", Lab on a Chip (2019)

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A practical guide to IACS

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, .., T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, "A practical guide to intelligent image-activated cell sorting", Nature Protocols (2019)

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Intelligent image de-blurring

F. Zhang, C. Lei, C.-J. Huang, H. Kobayashi, C.-W. Sun, and K. Goda, "Intelligent image de-blurring for imaging flow cytometry", Cytometry Part A (2019)


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